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No.2 seed Medvedev, who won the Rome event last year, was tested by Draper, the world No.4 saving seven of 10 break points faced in a one-hour, 47-minute contest.

Draper was in the ascendency when he broke Medvedev's serve to make it 5-5 in the first set, but Medvedev hit straight back before serving out the opener.

The Russian stepped things up from there and raced into a 5-1 lead in the second set, one Draper was unable to overturn as Medvedev teed up a last-32 clash with Hamad Medjedovic.

In the women's draw, four-time grand slam champion Osaka overcame No.10 seed Daria Kasatkina in another impressive straight-sets triumph, two days after recording her first clay-court win over a top-20 opponent in Marta Kostyuk.

She eased to a 6-3 6-3 victory and will now face China's Qinwen Zheng for a place in the quarter-finals.

Coming into this year's Italian Open, Osaka was 0-8 throughout her career against top-20 opponents on clay, but she has now recorded two such wins in a row for the very first time.