Alexander Isak netted in both halves as the Magpies came from behind, with Bruno Guimaraes helping to complete the turnaround after Anel Ahmedhodzic's early opener.

Callum Wilson rounded off the scoring after Ben Osborn's own goal had taken the game away from Chris Wilder's side, sending it back to the EFL Championship for next season.

Newcastle stays in seventh place, four points above West Ham United in eighth, while the Blades sit bottom of the table after a 25th league defeat of the season.

On a day when United needed to win, it got off to a fast start as Gustavo Hamer set up Ahmedhodzic for a close-range headed finish after just five minutes.

However, Isak equalised for the hosts as he scored for the seventh home game in a row, slotting into the bottom-left corner just before the half-hour mark.

The Blades regained momentum shortly after, and Ben Brereton Diaz saw a shot blocked on the line by Dan Burn before Mason Holgate flicked a header against the woodwork from the resulting corner as the teams headed into the break level.

However, Newcastle took advantage of some slack defending to go ahead as Guimaraes netted his fifth goal of the season with an unmarked diving header.

Holgate then gave away a penalty for a clumsy challenge on Anthony Gordon just before the hour mark, which Isak confidently dispatched.

United’s misery was further compounded just four minutes later when Osborn inadvertently flicked the ball into the back of his own net.

Wilson then rifled a fifth into the top-right corner to add further embarrassment as the Blades' relegation was confirmed.

It has been a tough season for the Blades, who became the first team to have their relegation from the Premier League rubber-stamped this season.

They sit bottom of the table with just 16 points after winning only three matches this season, conceding 97 goals, the most in a 38-game season in the competition's history.

Despite a spirited start to the game against Newcastle, United could not build on that to extend its time in the Premier League, and it will be playing second-tier football again next term.