The Argentina midfielder controlled a clearance from a corner just outside the box before unleashing a breathtaking shot into the top-right corner with just six minutes remaining.

The win leaves Atletico with 70 points from 35 games, and eight points ahead of fifth-placed Athletic Bilbao, while Celta is 16th with 34 points, five points above the drop zone.

Diego Simeone's hosts had launched a late offensive effort but remarkable saves from Celta goalkeeper Vicente Guaita kept them at bay until De Paul's stunner clinched three points.

Atletico can secure a spot in the UEFA Champions League next season with victory away at Getafe on Thursday (AEST).