Argentina national team coach Lionel Scaloni named the forward and midfielder to the 24-player roster for the 14 November international.

Inter Miami and Nashville FC split the first two matches of their MLS Cup playoff series, with the decisive Game 3 on Sunday. Should Inter Miami advance, the Eastern Conference semifinals would not begin until 22 or 23 November.

The pair did represent Argentina for two friendlies in October during the MLS regular season, with Messi playing in one and De Paul both matches against Venezuela and Puerto Rico.

Scaloni apparently took into account Argentina's Primera Division not pausing matches during the November international window and did not select any players from those squads.

"We spoke with Scaloni to ensure that players from Argentine football teams that are playing decisive matches in the Clausura Tournament are not called up," Argentine soccer federation president Claudio Tapia said.

Argentinian Emiliano "Dibu" Martinez, 33, a goalkeeper for Aston Villa of the Premier League, did not get the call from the national team for the friendly.

Messi, the MLS Golden Boot winner and MLS MVP favorite, was selected to the an MLS Best XI list this season. With 29 goals and 19 assists, the Inter Miami forward was one goal contribution shy of the league-record 49 set by Carlos Vela in 2019 and could be the first back-to-back MVP in league history.