Runner-up to Ash Barty at Wimbledon last July, Pliskova has endured a stop-start 2022 campaign.
The Czech missed the first two months with a hand injury, while suffering first-round exits in Indian Wells, Miami and Madrid.
But despite being taken to a decider by her French opponent, the top seed hit 16 aces on the way to reaching the last eight.
Second seed Angelique Kerber also required a deciding set to progress to her first quarter-final of the campaign; the three-time Grand Slam winner overcoming Aliaksandra Sasnovich 6-2 3-6 6-4.
Fourth and ninth seeds Elise Mertens and Viktorija Golubic also advanced to the last eight following straight-set wins over Anna-Lena Friedsam and Fiona Ferro respectively.
However, there was no joy for top seed Garbine Muguruza over in Rabat; the two-time Grand Slam champion was beaten 2-6 6-4 6-1 by world number 85 Martina Trevisan.
The Italian's reward is a quarter-final showdown with seventh seed Arantxa Rus, who saw off Dalma Galfi 6-4 6-2.
Mayar Sherif was another seed to tumble; the Karlsruhe champion lost 4-6 7-6(5) 6-1 to Claire Liu, who triumphed in the Trophee Lagardere last week.
Third seed Nuria Parrizas Diaz recovered from losing the opening set to defeat Kristina Mladenovic 4-6 6-3 6-0, while Anna Bondar hit seven aces as she overcame Kristina Kucova 6-3 6-3.