The 30-year-old returned to Atletico Madrid from Barcelona in a high-profile transfer at the end of August following two largely underwhelming campaigns at Camp Nou.
Griezmann was expected to revive his career in the Spanish capital, but he has managed just one goal and no assists in seven appearances in his second spell with Atletico.
That solitary strike came in last week's 2-1 win over Milan in the Champions League, though he was again left out of Atletico's starting lineup for Sunday's (AEDT) showdown with Barcelona.
He has been named in Deschamps' 23-man squad for this week's Nations League Finals, which will see France face Belgium in the semi-finals on Friday.
Les Blues will then either take on Italy or Spain in Sunday's final or third-placed play-off, depending on the outcome of both semi-finals.
And Deschamps has no concerns about using Griezmann, who has 41 goals in 98 caps for France, in those matches.
"His goal in the Champions League was very positive," Deschamps said at a news conference on Monday. "Even though he didn't start, that goal will give him confidence.
"He has returned to a club he knows well, but with different players around him. He can't just click his fingers.
"But because of his qualities and state of mind, I do not worry about him. I know he will be happy to join up with the France team."
Griezmann played a full part for France in their World Cup semi-final clash with Belgium en route to lifting the trophy in 2018, setting up Samuel Umtiti's winning goal.
The Nations League presents France with a chance to add to that triumph, having exited Euro 2020 at the last-16 stage, but they must overcome two sides ranked in the world's top eight.
"There is a title at stake; we have a semi-final to play against one of the best teams in the world," he said.
"With Italy and Spain on the other side, there are four of us fighting for this title. We did everything to qualify for this final phase in a very tough group.
"We want to get this title. Before there were two titles: the Euros and the World Cup. Now there is the Nations League. Winning it is our goal."
Belgium have named a vastly experienced squad for the Finals, with Jan Vertonghen, Axel Witsel, Toby Alderweireld and Eden Hazard all boasting over 100 caps.
Roberto Martinez's men only reached the quarter-finals of Euro 2020, where they were beaten by tournament winners Italy – their only defeat in 17 matches and one of only two defeats in 31 games since November 2018.
Ranked number one in the world, Deschamps acknowledged France face a big task against Belgium on Thursday.
"They have evolved well, with six or seven players on 100 or more caps," he said. "They are the best team in the FIFA rankings and have a very experienced core.
"It is a beautiful generation of players, but one that has not yet had the happiness of success at the Euros or World Cup."
Deschamps added: "It's going to be a fight at a physical, tactical and technical level. There is a lot of respect between myself and Roberto Martinez and also between the players.
"But there is of course a rivalry there because we are border countries, which we also have with Italy and Spain.
"There was also the 2018 semi-final we played, but this match cannot change what happened then. That will not have too much importance this week."