Messi and Barcelona face Napoli at the Stadio San Paolo in the first leg of their Champions League last-16 tie.
It has led to fresh comparisons between Messi and Diego Maradona, an Argentina great who starred at Napoli.
Asked if Messi could emulate Maradona and sign for Napoli, Pique told a news conference: "You can never say never in football, but I guess that is complicated.
"You should ask him as he decides his future. I would like him to retire with us. I can't tell you more."
Messi has scored 23 goals in 28 games in all competitions for Barcelona this season.