WATCH England v France LIVE on beIN SPORTS this Sunday from 3.45am AEDT | available via Foxtel, Kayo Sports, Fetch TV & beIN SPORTS CONNECT
Malins gets the nod at full-back, with Elliot Daly dropping to the bench in three changes made to the side by Eddie Jones.
Hooker Luke Cowan-Dickie is preferred to Jamie George, while Charlie Ewels takes Jonny Hill's place in the second row in an England side that will not be retaining their title after a defeat to Wales last time out.
Anthony Watson will win his 50th Test cap as the defending champions attempt to strike a blow to France's bid to claim the title with a victory in Le Crunch.
France return to action a month after they made it two wins out of two with a defeat of Ireland in Dublin, with their clash against Scotland postponed due to a coronavirus outbreak in the camp.
Head coach Fabien Galthie, who was among those to test positive for COVID-19, has named fit-again centre Vakatawa in midfield alongside Gael Fickou, with Arthur Vincent unavailable.
Teddy Thomas returns on the wing in place of the injured Gabin Villier, while Romain Taofifenua comes into the team after Bernard Le Roux was ruled out.
Dylan Cretin is preferred to Anthony Jelonch in the back row as the fit-again Romain Ntamack has to settle for a place on the bench when France go in search of a first win at Twickehham since 2007.
England: Max Malins, Anthony Watson, Henry Slade, Owen Farrell, Jonny May, George Ford, Ben Youngs; Mako Vunipola, Luke Cowan-Dickie, Kyle Sinckler, Maro Itoje, Charlie Ewels, Mark Wilson, Tom Curry, Billy Vunipola.
Replacements: Jamie George, Ellis Genge, Will Stuart, Jonny Hill, Ben Earl, Dan Robson, Ollie Lawrence, Elliot Daly
France: Brice Dulin, Teddy Thomas, Virimi Vakatawa, Gael Fickou, Damian Penaud, Matthieu Jalibert, Antoine Dupont; Cyril Baille, Julien Marchand, Mohamed Haouas, Romain Taofifenua, Paul Willemse, Dylan Cretin, Charles Ollivon, Gregory Alldritt.
Replacements: Camille Chat, Jean-Baptiste Gros, Dorian Aldegheri, Cyril Cazeaux, Cameron Woki, Anthony Jelonch, Baptiste Serin, Romain Ntamack.