A Karim Benzema penalty and Marco Asensio goal saw Madrid record a 2-0 win on Saturday (AEST), moving four points clear of rival Barcelona with three games left.
Madrid was awarded a spot-kick for the third straight game, while the VAR was needed after Asensio's goal was initially incorrectly ruled out for an offside decision against Benzema.
Varane, who helped Madrid keep a clean sheet for the fifth straight game, was unfazed by any talk decisions were going his team's way.
"Outside noise doesn't matter to us. We are focused on winning and giving everything on the pitch," the defender said.
"We don't control the VAR, we control the effort and attitude we show on the pitch."
Madrid is closing in on its first league title since 2016-2017, with Barcelona having clinched the past two crowns.
Varane said Madrid still had finals to play ahead of matches against Granada, Villarreal and Leganes to finish the league season.
"We are focused on our objective and we have three finals left," he said.
"It was important to win, of course, but it is very important to keep a clean sheet. That gives us a lot of confidence.
"We will continue with the positive dynamics we have."