Barca hosts Simeone's Atletico Madrid amid a difficult situation, with media reports claiming Setien and his coaching staff are at odds with key players.
A clip from Barca's 2-2 draw with Celta Vigo appeared to show Lionel Messi ignoring Setien's assistant Eder Sarabia.
Although Setien conceded it is normal to have occasional differences, he insisted the squad is unified despite the apparent issue with Sarabia and the fact certain publications have suggested the manager himself has a strained relationship with Messi.
Simeone, who is rarely forthcoming regarding internal matters in news conferences, was typically reluctant to appear as if he was offering an opinion on Barca's problems, though he did stress the importance of squad harmony.
"You know me, I don't give my opinion on what's going on in other dressing rooms," Simeone said. "I just make an opinion on ours. We need to keep it protected, always take care of it and always manage the feeling of the players, which is the most important for a squad.
"The most important thing is to manage, in my team, the emotional part, which I consider to be the key part."
When asked how he would solve issues similar to those appearing at Barca, he added: "I wouldn't tell you, and I would try to solve it naturally in our camp, which is the dressing room or the training session.
"A cup of coffee could also be there in any informal chat that could help for solving any internal issue."