Antoine Griezmann laid on two goals for Angel Correa after Nicolas Jackson put Villarreal ahead early on, but Axel Witsel's red card saw Diego Simeone's side come under mounting pressure, which told when Pascual converted two minutes into stoppage time.

That meant Atleti finished the season one point adrift of their city rivals in third, despite Los Blancos labouring to a 1-1 draw with Athletic Bilbao on Monday (AEST).

Pablo Barrios' error was punished as Villarreal went ahead after nine minutes, the teenager's miscued header teeing up Jackson for a powerful finish across goal. 

Atleti levelled when Correa turned Griezmann's clever free-kick home nine minutes later, and the France international teed up Correa again with the latter rounding Filip Jorgensen to put the visitors 2-1 up after the break.

With Atleti seemingly heading for second place, Witsel was dismissed for fouling Giovani Lo Celso as the last man, and Villarreal made their numerical advantage count in the season's dying moments, Pascual converting a rebound to condemn Simeone's side to third.