The midfielder was back in Denmark's squad for the first time since suffering a cardiac arrest at UEFA Euro 2020 and made an instant impact after being brought on at half-time.
Eriksen's well-taken goal, coming at the ground where he made a name for himself with Ajax, got Denmark back into the game after the hosts opened up a 3-1 lead at the break.
CHRISTIAN ERIKSEN SCORES TWO MINUTES INTO HIS RETURN TO INTERNATIONAL FOOTBALL!!! pic.twitter.com/BztWOVLGqM— ESPN FC (@ESPNFC) March 26, 2022
Steven Bergwijn and Nathan Ake netted either side of Jannik Vestergaard's leveller before Memphis Depay converted a penalty, with Bergwijn rounding things off after Eriksen's strike.
Netherlands had already tested Kasper Schmeichel three times before Bergwijn met Daley Blind's left-wing cross and headed in a 16th-minute opener.
Denmark's response was a swift one, with Joakim Maehle sending in a cross for Vestergaard to glance in a leveller four minutes later after Jesper Lindstrom's free-kick was blocked.
Ake restored Netherlands's lead shortly before the half-hour mark with another headed goal, finishing from close range once picked out by a fine Steven Berghuis delivery.
Louis van Gaal's men had some breathing space before the interval thanks to a Depay penalty, which was awarded for Vestergaard's challenge on Berghuis.
Denmark lost Yussuf Poulsen and Thomas Delaney to injury but was given a lifeline when Eriksen converted fellow substitute Andreas Skov Olsen's pass with a first-time finish.
Bergwijn's curled effort with 20 minutes to go ended Denmark's hopes of claiming a draw, though there was still time for Eriksen to send a long-range shot off the post.