Isco was back in the squad after being left out entirely for the UEFA Champions League win at Roma in midweek, but Santiago Solari again opted not to name the Spain playmaker in the XI.

Marcos Llorente thrived in midfield in Isco's absence but Madrid needed an eighth-minute intervention from Wass to take the lead on Sunday (AEDT).

Dani Carvajal crossed from close to the byline on the right wing and Wass sent an attempted clearing header flying past goalkeeper Neto, while Thibaut Courtois was in fine form at the other end.

Vazquez – who also scored in the 2-0 win over Roma – slotted in the decisive second for Madrid with seven minutes to go, the goal surviving a lengthy VAR review, to claim all three points.

Madrid started well and took the lead in just the eighth minute, albeit in fortuitous circumstances.

Carvajal won back possession deep in the Valencia half and delivered a chipped cross to the front post that Wass could only guide into the roof of his own net.

Neto made a brilliant save to deny Gareth Bale and a long-range Dani Parejo shot was easily dealt with by Courtois.

Valencia should have equalised in the 53rd minute, Santi Mina racing onto an excellent Parejo ball over the top of the Madrid defence but hitting his shot too high to trouble the Belgium goalkeeper.

Another Parejo ball caused chaos in the Madrid box but, arriving at the back post, defender Gabriel was stretching and sent his volleyed effort flying over the crossbar.

Madrid almost extended its lead in the 72nd minute when substitute Marco Asensio was teed up by Llorente, but Cristiano Piccini made a sensational block.

After Courtois brilliantly denied Michy Batshuayi, Isco was introduced for the last 10 minutes, with Karim Benzema then teeing up Vazquez for the clinching goal to ensure Madrid moved up to fifth in the LaLiga table.