Life after Nuno Espirito Santo began brilliantly for Spurs, with Son Heung-min, Lucas Moura and an own goal from Jacob Rasmussen giving them a firm grip on the game after just 28 minutes. 

However, Rasmussen atoned for his error and Matus Bero brought Vitesse – who won the reverse fixture 1-0 – back to within a goal of restoring parity before half-time, with a previously jubilant Tottenham Hotspur Stadium falling flat. 

Romero's second booking with 30 minutes remaining increased the pressure on Conte's men, but Danilo Doekhi and Markus Schubert also received their marching orders in the final 10 minutes as Vitesse missed a chance to complete a historic comeback.

Ben Davies was perhaps fortunate not to concede a third-minute penalty for a clumsy tackle on Nikolai Frederiksen and Spurs took advantage of that reprieve, Son scoring on the follow-up after Schubert failed to hang onto an effort from Lucas.

Son rattled the upright but Tottenham soon stormed clear as Lucas added a cool finish to Harry Kane's throughball and Rasmussen scored an own goal while attempting to stop Kane steering Davies' mishit shot home. 

Hugo Lloris did brilliantly to tip Sondre Tronstad's long-range shot over the crossbar, but Rasmussen headed home from the resulting corner and Bero punished a mistake from Lucas to curb the enthusiasm that was building in the Tottenham Hotspur Stadium. 

The pace of the game was far slower after the restart and Spurs were reduced to 10 men when Romero received a second yellow card for pulling down Lois Openda. 

Vitesse's hopes of completing the comeback and causing an upset evaporated in the closing stages, though, as Doekhi committed a second bookable offence and Schubert got a straight red for handling outside his area.