Nuno Espirito Santo's side look destined for a charge to the title and they showed little sign of slowing up at Molineux on Wednesday (AEDT) with all three goals arriving after half-time.
Neves opened the scoring with a fine free-kick in the 57th minute and less than 120 seconds later the advantage was doubled as Douglas smashed home from Ivan Cavaleiro's low cross.
Jota's close-range strike completed the scoring 10 minutes from time as Wolves moved a dozen points clear of second-placed Derby County.
At the opposite end of the table, Birmingham City climbed off the bottom above Sunderland thanks to a 2-0 win at Reading.
Jacques Maghoma broke the deadlock midway through the first half before Sam Gallagher made it two in the 64th minute as the Blues enjoyed back-to-back victories.
Wednesday's other game saw Fulham storm back from a goal down to thrash 10-man Ipswich Town 4-1 at Craven Cottage, Ryan Sessegnon and Aboubakar Kamara each netting a brace in a seven-minute blitz which started midway through the second period.
Ipswich had gone in front through Joe Garner on the stroke of half-time but was left to rue Jordan Spence's straight red card for a challenge on Kamara in the 54th minute.