Held by Leyton Orient as they started their pre-season preparations last Sunday (AEST), Spurs offered a more encouraging display this time around.
Son Heung-min opened the scoring in the 11th minute with a simple finish after Steven Bergwijn had been played through on goal.
Lucas Moura made it 2-0 with a near-post header from a corner three minutes later and Dele Alli helped his case for a larger role in 2021-22 having fallen out of favour under Jose Mourinho last season.
He bundled home Son's right-wing cross as Tottenham went 3-0 up in the 38th minute before lesser experienced members of Santo's squad were given a run out in the second half.
Tottenham travels to MK Dons for its next friendly on Thursday.