Carlos Alcaraz saw his hopes of a third straight Madrid Open crown dashed on Wednesday, as Andrey Rublev fought back to seal a statement quarter-final win over the defending champion.

Alcaraz had been pushed close in the last 16 by Jan-Lennard Struff on Tuesday, requiring two tie-breaks to see off the German in three sets, and those exertions seemed to take their toll as he produced a below-par display on Wednesday.

Seven unforced errors from Rublev helped the home favourite take the opener, but he appeared to tire from there as his seventh-seeded opponent fired in 27 winners in a 4-6 6-3 6-2 victory.

Rublev broke Alcaraz's serve in the first and fifth games of the decider, also serving impressively to deny the Spaniard a single break point after a nervous first hold. 

Alcaraz's exit ended home interest in the tournament, just one day after five-time champion Rafael Nadal was dumped out in the last 16 by Jiri Lehecka.

Speaking to Sky Sports Tennis, Rublev said: "I can't believe that I was able to stay calm throughout the match. I didn't say a word and even I'm impressed by that!

"I want to believe that I have been working on this because if not, then I'm stupid. I just thought to myself to keep trying, keep fighting, keep believing in yourself."

Data Debrief: Major scalp for Rublev

To say Rublev entered Wednesday's match as the underdog would be an understatement. Alcaraz was looking to become the first player to win three straight Madrid Open singles titles, and was 24-0 in Spanish clay-court events since the start of 2022.

Rublev, though, was not overawed by the occasion and punished a sluggish performance from the world number three. Wednesday's win was his first over a top-three opponent since 2022, and he will now face either Taylor Fritz or Francisco Cerundolo in the last four.