Liverpool manager Jurgen Klopp rang the changes with his team already secure as Group E winners and with an eye on the weekend's Premier League game against rivals Manchester United, starting six players aged 20 or younger.

Saint-Gilloise, who needed a victory to keep alive their hopes of pipping Toulouse to second place, took the lead through Mohamed Amoura before Jarell Quansah hit back for Liverpool.

Cameron Puertas restored the hosts' advantage two minutes before half-time with a low strike which beat Caoimhin Kelleher at his near post.

Klopp threw on Joe Gomez, Ryan Gravenberch and Darwin Nunez in the second half, but Saint-Gilloise held on for a famous win, although the Belgians dropped into the Europa Conference League play-off round after Toulouse beat LASK Linz 2-1 in the group's other game to finish second.