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The Blues picked up one of their best Premier League results of the season on Friday (AEST) in beating Ange Postecoglou's Tottenham Hotspur 2-0 on home soil.

Another London derby now awaits, but Pochettino believes the quick turnaround in matches could work against his side.

"It is the most dangerous game because now we have to keep the same mentality for Sunday," he said.

"We are playing a team who are so strong, have physicality and West Ham are having a fantastic season and have been competing in Europe.

"We need to recover players. We don't have too many options to add fresh people to the squad and they have had the whole week to prepare."

Inconsistent Chelsea has often struggled to build on positive results this season, explaining why it sits eighth on the Premier League.

Pochettino's side is two points better off than West Ham with a game in hand as they both desperately attempt to keep their top-six hopes alive.

West Ham is winless in five matches in all competitions, seeing it drop down the Premier League and exit the UEFA Europa League.

Doubts remain over manager David Moyes's future, with his current deal expiring at the end of the campaign, but he is focusing only on Chelsea.

"We're going to have to play well to get a result against them," Moyes said at his pre-match press conference.

"I think [Pochettino's] had a difficult job, and they've started to hit form. Mauricio is a great manager, and they have a lot of good, young players.

"There are lots of tough stadiums to go to, Stamford Bridge being one of those. We'll go there and do everything we can to get a result."