The 41-year-old Argentinian, who guided Miami to the club's first MLS Cup title, said his surprise departure was due to "personal reasons".

"I want to let everyone know that, for personal reasons, I have decided to end my tenure as head coach of Inter Miami CF," Mascherano said in a statement released by the club.

"First and foremost, I would like to thank the Club for the trust they placed in me, every employee who is part of the organization for the collective effort, but especially the players, who made it possible for us to experience unforgettable moments."

The former Barcelona and Liverpool midfielder took over at Miami in January 2025 and oversaw 67 matches, including the franchise's run to the round of 16 at the Club World Cup, where they were defeated by UEFA Champions League winners Paris Saint-Germain.

"Javier will forever be part of this Club's history and will always hold a special place in the Inter Miami CF family," managing owner Jorge Mas said.

"We respect his decision and are deeply grateful for everything he contributed, wishing him nothing but the very best in his professional and personal future."

Argentinian Guillermo Hoyos will take charge of the team for the "upcoming matches", the club said.

After seven rounds this season, Inter Miami sit third in the MLS Eastern Conference.

Messi, a 2022 World Cup winner and eight-time Ballon d'Or laureate, is the jewel in the crown of Miami's squad, which also includes Luis Suarez and Rodrigo De Paul.