Atalanta forward Lookman, a former winner of the African footballer of the year award like Osimhen, opened the scoring after 20 minutes from an Akor Adams assist.

Osimhen had started the game without wearing his trademark mask but restored the face covering before netting Nigeria's second goal on 25 minutes after a Lookman cross from the left was helped on by Adams.

The Galatasaray forward then scored again from another Lookman delivery just after half-time, his third goal in three games after seven Cup of Nations appearances without finding the net.

Lookman was again the provider as Sevilla forward Adams rifled in the fourth quarter of an hour from the end, as the Super Eagles recorded the biggest win in an AFCON knockout tie since Egypt hammered Algeria 4-0 in the semi-finals at the 2010 tournament in Angola.

"I am very happy. It was a good performance from the team, scoring four goals. There is lots to be happy with. Hopefully we can keep up the good work," said Lookman, named man of the match.

Mozambique go home but this Cup of Nations can go down as a success for them after they reached the knockout phase for the very first time.

Determined to make up for their failure to qualify for the World Cup, Nigeria march on to a last-eight tie on Saturday in Marrakesh against either Algeria or DR Congo.

Those teams clash in Rabat in the last 16 on Tuesday and a victory in that game for DR Congo would offer Nigeria a chance to avenge their defeat on penalties against the Leopards in a World Cup qualifying play-off in November.

The final last-16 ties take place on Tuesday with Algeria facing the Congolese before the Ivorians meet West African neighbours Burkina Faso in Marrakesh.