Real Madrid dropped points for the first time in LaLiga under Julen Lopetegui, Isco's header salvaging a 1-1 draw at Athletic Bilbao.
Iker Muniain bundled home from close range to give Athletic a first-half lead in a bad-tempered clash at San Mames on Saturday, while Unai Simon impressed in goal for the hosts.
But Toni Kroos sent Gareth Bale clear with an excellent chipped pass and substitute Isco flicked in the Wales winger's cross to level shortly after his second-half introduction.
Madrid pressed for a winner but could not beat Simon a second time, leaving Lopetegui's men two points behind league leaders Barcelona, who maintained their perfect record.
63- Goal! Athletic Club 1, Real Madrid 1. Isco (Real Madrid) header from very close range to the bottom left corner. Assisted by Gareth Bale with a cross.
32- Goal! Athletic Club 1, Real Madrid 0. Iker Muniain (Athletic Club) right footed shot from very close range to the bottom right corner.