Olivier Giroud will miss Thursday's (AEDT) EFL Cup quarter-final against Southampton because of a groin injury, but Lucas Perez is ready to make his comeback from an ankle problem.
France international Giroud was expected to start after having to settle for a spot on the bench behind Alexis Sanchez in recent weeks.
Giroud's absence could see Arsene Wenger give Perez the nod, with the Arsenal boss planning to field a mixture of first-team players and youngsters.
"Lucas is in the squad," Wenger said.
"We will have a mixture of youth and experience, but still 90 per cent of the first-team squad."
Mathieu Debuchy, meanwhile, is also unavailable because of a hamstring problem, with the wing-back to undergo a scan on Wednesday (AEDT).
"We do not have the results yet," Wenger added.