Defensa y Justicia hosted Independiente de Medellín in a direct clash in Group A of the CONMEBOL Copa Sudamericana, where the Argentinians and Colombians shared points after a 1-1 draw, with goals from Brayan Muñiz for Medellin and an own goal by José Ortiz for Defensa y Justicia.

With this result, Defensa y Justicia remains in third place in the group with five points, while Independiente stays in second place with a total of ten points.