Florian Wirtz’s penalty took Bayer Leverkusen to within touching distance of the Bundesliga title as Bayern Munich squandered a two-goal lead to leave the leaders 16 points clear.

Wirtz struck from the spot eight minutes into added time at the end of the first half after Christopher Trimmel had handled to secure a 1-0 win at Union Berlin, who had seen Robin Gosens dismissed for a second bookable offence minutes earlier.

Xabi Alonso’s men could win the league next weekend, when they face Werder Bremen on Sunday, a day after Bayern host Cologne with both sides have just 18 points to play for.

The reigning champions, who set out this season looking for a 12th successive title, conceded further ground as they went down 3-2 at Heidenheim.

Harry Kane’s 32nd league goal of the season and Serge Gnabry’s strike had given the visitors a healthy half-time lead, but goals from Kevin Sessa and Tim Kleindienst inside a minute dragged the promoted side back into it before Kleindienst snatched a famous victory 11 minutes from time.

Serhou Guirassy’s 64th-minute strike sent third-placed Stuttgart level with Thomas Tuchel’s side on points courtesy of a 1-0 win at Borussia Dortmund, who dropped out of the top four as a result.

Lois Openda claimed a double to help RB Leipzig maintain the pace in the race for a Champions League spot with a 4-1 victory at Freiburg.

Openda’s contribution came in between Amadou Haidara’s first-minute opener and Benjamin Sesko’s strike nine minutes after the restart with substitute Vincenzo Grifo reducing the deficit.

Lee Jae-sung scored twice to help Mainz to a 4-0 home win over bottom-of-the-table Darmstadt with Andreas Hanche-Olsen and Brajan Gruda also on the scoresheet, while substitutes Steffen Tigges and Luca Waldschmidt struck at the death as Cologne recovered from Felix Passlack’s opener to beat Bochum 2-1.

AC Milan maintained their seemingly vain pursuit of Serie A leaders Inter Milan with a regulation 3-0 win over 10-man Lecce.

Christian Pulisic and Olivier Giroud gave the Rossoneri control inside the first 20 minutes at the San Siro before the visitors had Nikola Krstovic dismissed, and Rafael Leao wrapped up a fifth successive league victory 12 minutes after the break.

Gianluca Mancini handed Roma boss Daniele De Rossi victory in his first Derby della Capitale as he headed home Paulo Dybala’s corner to clinch a 1-0 victory over Lazio.

M’Baye Niang came off the bench to end Empoli’s losing streak with a 3-2 victory over Torino.

Niang scored in the fourth minute of added time after Duvan Zapata had twice equalised to cancel out goals from Nicolo Cambiaghi and Matteo Cancellieri.

Goncalo Ramos scored Paris St Germain’s 100th goal of the season as they hit back late to deny bottom-of-the-table Clermont a second successive Ligue 1 victory at the Parc des Princes.

Habib Keita stunned the home crowd when he opened the scoring for the visitors 13 minutes before the break, and the locals were even less amused in first-half stoppage-time when 17-year-old Senny Mayulu’s long-range equaliser was ruled out after a VAR review.

Achraf Hakimi and Ramos both hit the bar as the hosts laid siege to the Clermont goal, but it was Ramos who levelled five minutes from time with Kylian Mbappe, making his 300th appearance for the club as a 67th-minute substitute, sliding him in to snatch a 1-1 draw.

Emmanuel Sabbi’s late penalty ensured Le Havre emerged from their trip to Lens with a 1-1 draw as he cancelled out Przemyslaw Frankowski’s opener to further dent the home side’s hopes of a top-four finish.

In Spain, substitute Alex Berenguer ended Athletic Bilbao’s 40-year wait for Copa del Rey glory with the decisive penalty in a shoot-out victory over Real Mallorca.

Raul Garcia, Iker Muniain, Vesga and Berenguer, who were all introduced from the bench, scored from the spot as keeper Julen Agirrezabala saved from Manu Morianes and Nemanja Radonjic blazed over to hand the Basque club the trophy they last win as part of a league and cup double in 1984.

Oihan Sancet’s 50th-minute strike had earlier cancelled out Dani Rodriguez’s first-half opener at the Estadio Olimpico de la Cartuja in Seville, but neither team could find a winner in 120 minutes of football.