Novak Djokovic is out of the Italian Open after a straight-sets defeat by Alejandro Tabilo in the third round on Sunday.

Tabilo recorded the biggest win of his career with a dominant performance, winning 6-2, 6-3 in his maiden ATP Tour clash with the Serbian.

Djokovic, who was hit on the head by a water bottle following his second-round win over Corentin Moutet, struggled to get going as he saw his serve broken four times.

Tabilo clinched the opening set in style, making few errors, and Djokovic failed to mount a comeback in the second, with double faults costing him at key moments, including one on the final break serve.

The Chilean advances to the fourth round at a Masters 1000 event for just the second time after Indian Wells in 2023. His next opponent will be Karen Khachanov, who saw off Francisco Cerundolo 6-2, 6-4. 

Data Debrief: Big winner

Tabilo is the second player from Chile to defeat the World No.1 in ATP-1000 events after Fernando Gonzalez, who defeated Lleyton Hewitt at the Hamburg Masters in 2003, since the introduction of the format in 1990.

He is also the first Chilean to defeat a World No. 1 since Fernando Gonzalez beat Roger Federer at the 2007 Nitto ATP Finals Round Robin.

Djokovic, meanwhile, is made to wait for his 1100th match win.