Panama celebrated a famous win as Sunday's 1-0 victory gave them their first CONCACAF World Cup qualifying triumph over the United States.
USA entered the away fixture unbeaten in eight World Cup qualifiers against Panama, including six wins, and enjoying a 13-match undefeated streak across all competitions.
But Panama had other ideas thanks to Anibal Godoy, whose 54th-minute header secured an unlikely victory in Panama City on the road to Qatar 2022.
In wild scenes, Godoy – who plays in MLS for Nashville – headed home Eric Davis' corner at the near post.
It was a rough outing for Gold Cup champions USA, who appeared out of sorts having failed to produce a single shot on target throughout the fixture at Estadio Rommel Fernandez.
Panama are now level with leaders USA and Mexico on eight points, though El Tri are due to face Honduras on Sunday.