Reigning world champions France start their Group D campaign against Ukraine on Thursday before taking on Kazakhstan and Bosnia-Herzegovina on Sunday and Wednesday respectively.
Les Bleus are expected to comfortably book their place in Qatar next year and Deschamps expects his forward trio to shine again after their heroics won the 2018 tournament.
"I'm not going to separate them from the rest of the team, but when you look at the number of goals and assists that the three provide, that's what allowed the France team to be world champions," he told a media conference.
"They know each other; it is automatic. The experience they have is something important. It is up to them to maintain this level of performance."
Mbappe has enjoyed another fine season for Paris Saint-Germain and is Ligue 1's top scorer with 20 goals in 21 starts.
He has also laid on six goals for his team-mates – second behind only Angel Di Maria (eight) for Mauricio Pochettino's side.
Mbappe largely plays on the left of a front three for his club and Deschamps revealed he has spoken to the 22-year-old to ensure his position for France brings out the best in him.
"Kylian has the ability to play in all offensive positions," Deschamps said. "In his club, he is mainly used in a position on the left, even if he has a lot of freedom.
"Sometimes he plays in the middle, where he is also efficient. On the right, he plays less. I discuss it with him to make sure he is happy [where he plays]."
Trying to force his way into Deschamps' forward line will be Ousmane Dembele, who has not featured for France since November 2018.
Deschamps handed the Barcelona man his full debut back in September 2016 and, after injuries wiped out the vast majority of the 2019-20 season, he has returned to form this term.
Captain Hugo Lloris is pleased to see the 23-year-old back on the international scene and is hopeful he is in the right condition to make a positive impact.
"He has a fairly strong history with the France team as he was part of the World Cup group in Russia," the Tottenham goalkeeper said.
"He was held back by injuries, but we know all his qualities. We hope that his injuries are behind him and that he can look ahead.
"He is doing very good things with Barca. We know what he can bring and what he is capable of doing."