Julian Alvarez's first-half strike was all that separated Argentina from home side Ecuador until a stoppage-time penalty secured a 1-1 draw.
With both sides already punching their tickets to the Qatar World Cup, this fixture was more about national pride, and it was evident neither team was going to take it easy as a number of the biggest stars were included in starting line-ups, including Lionel Messi.
Playing in front of a raucous home crowd, Ecuador defended with fiery passion, which was rewarded in the 93rd minute.
Enner Valencia tucked home a rebound after seeing a penalty awarded by VAR saved, cancelling out Alvarez's 24th-minute opener.
Ecuador almost had a dream start in front of their home fans, with Robert Arboleda's header from a fifth-minute set-piece tipped over the bar by Geronimo Rulli, who then denied Alan Franco.
Argentina had over 60 per cent of possession in the first half and, after their dominance was mitigated by sloppy mistakes early, the pressure paid off when Alvarez broke the deadlock.
Alvarez's goal came after a cross in from the left wing found him at the penalty spot, and though his first-time shot was blocked by a lunging defender, he tucked away the rebound neatly, hard and low across the goalkeeper into the bottom left corner.
Angel Mena fired wide from the edge of the box at the end of a surging run and it looked as if Argentina, who went close with a Messi free-kick would leave victorious until an on-target header struck Lucas Martinez on the arm, with VAR awarding a penalty.
Valencia's initial attempt was saved by Rulli, but the rebound fell fortuitously at his feet for him to tap in the equaliser.
What does it mean?
Both teams have secured qualification to the World Cup, but Argentina managing to again avoid defeat means they are now 31 games unbeaten, a run that stretches back to the 2019 Copa America semi-fiinals.
Argentina face reigning European champions Italy on June 1. Ecuador can start to think about preparations for their first World Cup finals appearance since 2014.