Athletic Club defender Inigo Martinez withdrew himself from contention for a place in Spain's Euro 2020 squad because of concerns over his physical and mental health.
Ramos' absence would ordinarily mean a prominent role for Martinez, although he was another notable absentee, with Pau Torres, Diego Llorente, Aymeric Laporte, Eric Garcia and Cesar Azpilicueta comprising Luis Enrique's central defensive options.
Speaking at a news conference after the squad announcement, Luis Enrique did not go into detail over Martinez not being selected, simply saying there would be a statement after his briefing.
The 30-year-old then posted an explanation on social media, saying that he felt it was time to put his own wellbeing first for the good of both the national team and himself.
"These lines are very hard to write. The truth is that for some time I have not been 100 per cent physically or mentally to compete at the level of maximum demand required by the Athletic and national team jerseys," Martinez's statement read.
"I have come to the conclusion that, out of honesty with these shirts and with myself, I must stop. Take a step to the side to disconnect, recharge the batteries and quickly recover the strength that has always accompanied me.
"A few days ago I transferred this difficult decision to my club and to the national team, since I have been fighting all season to the fullest for my club and for the goal of participating in the Euro.
"I have left everything on the pitch for it, but I believe that sincerity is the best for the national team in this difficult challenge that lies ahead."
Martinez has played 28 times for Athletic in LaLiga this season, largely matching the levels he has set throughout a distinguished career in Spain's top flight, the bulk of which came with Basque neighbors Real Sociedad before moving to San Mames in 2018.
A 68.2 per cent tackle success rate sits alongside his overall output in LaLiga (68.9) and is better than his average in Bilbao (60.3).
He has won 57.3 per cent of duels contested in 2020-21, a slight drop when compared to his whole career (59.5) and stint at Athletic (61.1).
Martinez is also reliably smooth in possession, completing 82.8 per cent of his passes this season – putting him 11th among Spanish-qualified defenders to have played 2,000 or more minutes in the division. That is up on 79.4 per cent for Athletic overall and 79.6 in his career to date.