Manchester City completed a stunning comeback at the Santiago Bernabeu as Kevin De Bruyne's penalty secured a 2-1 victory over Real Madrid in the first leg of their Champions League last-16 tie.

Despite being the better side for much of a frenetic encounter in Spain, City – who lost Aymeric Laporte to injury in the first half – looked set to be heading for a defeat when Isco put Madrid ahead on the hour.

But De Bruyne, a peripheral figure in the first half, led the fightback, supplying the cross from which Gabriel Jesus headed home an equaliser before coolly slotting in from 12 yards after Dani Carvajal had brought down substitute Raheem Sterling.

And Madrid's frustrations were compounded with four minutes remaining, captain Sergio Ramos seeing red for a last-man challenge on Jesus as City secured a lead to take back to Manchester.