Isco will miss Real Madrid's Champions League clash with Bayern Munich on Tuesday after failing to recover from a sprained shoulder in time.
The Spain midfielder suffered the injury during the first leg of the semi-final on German soil, leading to him being substituted at the halfway stage of his side's 2-1 win.
Despite training with the squad on Monday, Isco's name does not feature in Zinedine Zidane's squad for the return fixture at the Santiago Bernabeu.
📝 This is our squad for Tuesday's Champions League semi-final second leg against @FCBayernEN!#APorLa13 pic.twitter.com/8JapLwi1hK
— Real Madrid C.F.🇺🇸🇬🇧 (@realmadriden) April 30, 2018
However, Nacho Fernandez - who has missed the past month of action due a thigh problem - is included.
The defender's return would be timely too, considering the reigning European champions are without regular right-back Dani Carvajal due to a hamstring strain.