Head coach Julian Nagelsmann announced at a news conference on Thursday the United States international sustained a calf injury in training and will be out for at least a week.
🗣️ Julian #Nagelsmann on team news: "There's some bad news. @tyler_adams14 pulled his calf yesterday. He will definitely miss Werder and Spurs. Otherwise, there's nothing new to report."— RB Leipzig English (@RBLeipzig_EN) February 13, 2020
🔴⚪ #DieRotenBullen #RBLSVW pic.twitter.com/3PfDzOu4ld
Leipzig face Werder Bremen in the Bundesliga on Saturday before taking on Jose Mourinho's Tottenham in north London four days later.
Adams, who turns 21 on Friday, has made five appearances in all competitions this season, having only returned from seven months out with a groin issue in December.
He started the 0-0 draw with Bundesliga leaders Bayern Munich on Saturday that left Leipzig winless in four games in all competitions.
However, Nagelsmann is confident his team are primed to reproduce their best form as they hit a crucial part of the season.
"Our football improved against Bayern. It's a step in the right direction. The game has given the players confidence; training has been full of determination and power this week," said Nagelsmann.
"The team lacked stability before Bayern. There have been a lot of new elements in training in recent weeks that challenged them.
"I'm confident we can shake off this mini struggle, though, and believe that we already have."