Marcus Rashford and Nick Pope have withdrawn from England's squad for their Euro 2024 qualifiers against Italy and Ukraine after sustaining injuries.
As confirmed by Chelsea head coach Graham Potter last week, Mason Mount has also pulled out through injury.
Pope reported an injury following Newcastle United's 2-1 win at Nottingham Forest on Friday, while Rashford suffered a knock during Manchester United's 3-1 FA Cup quarter-final victory against Fulham on Sunday.
Tottenham's Fraser Forster has been called up to replace Pope, though England boss Gareth Southgate has decided not to bring in cover for Rashford or Mount.
Veteran goalkeeper Forster has been getting game-time for Tottenham since Hugo Lloris' injury in February.
The 35-year-old has played 13 times for Spurs this season, keeping five clean sheets with a save percentage of 68.8.
Losing Rashford will be a particular blow for Southgate, with the United forward in the form of his life having scored 27 goals in 44 appearances for his club this season.
England play Italy at Stadio Diego Armando Maradona on March 23 before hosting Ukraine at Wembley Stadium three days later.