Jurgen Klopp's side, who most recently won the competition in 2019, face Real Madrid in Paris on May 28.
They have already won two trophies this season – the EFL Cup and FA Cup – and could still be in line for an unprecedented quadruple by the time the final rolls around.
NBA great James invested in Liverpool in 2011, and in a Twitter Q&A on Monday, the Los Angeles Lakers star was asked for his prediction ahead of the Madrid clash.
"4-3 US!!!! YNWA," James responded.
Following Liverpool's penalty shoot-out win over Chelsea in the FA Cup final on Saturday, James tweeted "YESSIR!!!!!! WE ARE THE #EmiratesFACup WINNERS!!!!!!! @LFC."