Manchester City will start their Premier League title defense at West Ham, while Frank Lampard will host his former club Chelsea with Everton on the opening weekend.
City pipped Liverpool to their fourth English top-flight crown under Pep Guardiola and there will be significant interest around their August 7 opener at London Stadium, where new signing Erling Haaland could make his debut after arriving from Borussia Dortmund.
Jurgen Klopp's Liverpool will aim to mount another title charge in the 2022-23 campaign and they go to newly-promoted Fulham for their first game.
Chelsea eased into third place last term and their first league game of the Todd Boehly era sees them travel to face Blues great Lampard at Everton, who narrowly avoided relegation to maintain their top-flight status.
Manchester United finished in a disappointing sixth last campaign, with a 4-0 thrashing at Brighton and Hove Albion a low point, and they host the Seagulls in what will be Erik ten Hag's first game in charge.
Arsenal will visit Crystal Palace on August 5 as the season's opening game, while promoted side Bournemouth are at home to Aston Villa.
Antonio Conte's Tottenham sneaked into the Champions League last season and open their campaign at home to Southampton, with Nottingham Forest playing their first top-flight fixture in 23 years away at Newcastle United, who climbed out of the relegation zone under Eddie Howe in the previous term.
Testing opening for Liverpool, Guardiola faces late Blues clash
Liverpool were in the hunt for an unprecedented quadruple for much of the 2021-22 season, but fell short and ended up with just the EFL Cup and FA Cup crowns to their name.
Klopp's side will be tested in the opening weeks of the season, facing four – United, Chelsea, City, and Arsenal – of the traditional 'big six' sides in the first 11 games, alongside a Merseyside derby at Everton on September 9.
The first clash between United and Liverpool will come just three matchdays into the season, with the Reds visiting Old Trafford on August 20.
Liverpool then head Chelsea and Arsenal either side of the late September international break, with champions City traveling to Anfield just a week after the Gunners trip.
Supporters in Manchester will eagerly await October 1 for the first meeting between United and City at Etihad Stadium, while the first north London derby between Tottenham and Arsenal comes on the same day.
The Premier League title race went down to the wire last campaign, and City could face a tough task if it does so again as they host Thomas Tuchel's Chelsea in an enticing clash on the penultimate weekend.
Premier League opening weekend fixtures:
Crystal Palace v Arsenal
Bournemouth v Aston Villa
Everton v Chelsea
Fulham v Liverpool
Leeds United v Wolves
Leicester City v Brentford
Newcastle United v Nottingham Forest
Tottenham v Southampton
Manchester United v Brighton and Hove Albion
West Ham v Manchester City