Hazard played a pivotal role as Chelsea thrashed Arsenal 4-1 to lift the Europa League trophy on Wednesday, with the Belgian scoring twice in Baku.
In the immediate aftermath he confirmed that it was probably his final outing in a Chelsea shirt ahead of an expected move to Madrid.
The Spanish giants have long been linked with the Belgium international, whose Chelsea contract expires next year.
The Premier League club are reported to be holding out for £100million for Hazard, and although David Luiz feels it will be tough to fill the void left by his friend's departure, the Brazilian has high hopes for Callum Hudson-Odoi.
"I think, if he goes, I just wish him all the best. He is a fantastic player, friend and guy.
"I've known him ever since he was so young here. I am so happy for him because the world knows who Eden Hazard is.
"It [moving on] is part of life. Some cycles finish, some cycles start. I think we have many, many talents within the club who can replace him.
"Callum [Hudson-Odoi] is great. Callum has known this club since he was young and he has the talents to one day try to be like Eden.
"It didn't start so well because of the injury [Hudson-Odoi suffered a ruptured Achilles tendon in April], but it is time for him to improve in other sides [of his game]."