Los Angeles Lakers star James has helped lead the fight for racial equality and social justice.
"Yeah, absolutely. I think he's got a way about him where he understands people and they are interested in things he has to say, or back, and believe in," he told a news conference on Tuesday.
"So, I think that presents yourself with a good combination to whatever platform that you want to support or take, that you have that ability."
Mahomes, 25, has already won a Super Bowl to go with a Super Bowl MVP and NFL MVP honors.
The quarterback said James was one of the athletes he had modeled himself on.
"There's a lot of great athletes that are doing things the right way. LeBron is one of them. He's someone that I can talk to and get advice from but there's others too," Mahomes said.
"There's a ton of people that are using their voice to make a difference in this world.
"I try and take from them and kind of use my own voice in my own way to make an impact in my community."