Kawhi Leonard will miss Game 5 of the Western Conference semi-finals, according to multiple reports, after the Los Angeles Clippers star was ruled out indefinitely with a right knee sprain.

Leonard, the two-time NBA Finals MVP, has played an instrumental role in levelling the seven-game series with the Utah Jazz at 2-2 after the Clippers fell into a 0-2 hole.

He scored 34 points in 31 minutes as the Clippers took Game 4 at Staples Center, the highlight a monstrous dunk over Derrick Favors.

But with the series now shifting back to Utah for Game 5, the Clippers now face the prospect of potentially being without Leonard for the rest of the series.

It could prove a potentially fatal blow to the Clippers' hopes of progressing to a Western Conference Finals matchup with the Phoenix Suns.

He leads the Clippers with 30.4 points per game in the postseason, comfortably ahead of Paul George (24.9).

Only three players in the league have had a greater scoring influence on victories for their respective teams during the playoffs.

Leonard has averaged 33.8 points per game in wins this postseason, a tally bettered by only Luka Doncic (37.3), Nikola Jokic (37) and Anthony Davis (34).

The Clippers, who have never reached the Conference Finals in their history, will look to take a 3-2 lead by overcoming Leonard's absence and the Jazz in Game 5 on Wednesday.