The first overall pick in the 2019 NBA Draft had 22 points, seven rebounds and three assists in 18 minutes of action for the New Orleans Pelicans in their 121-117 loss to the San Antonio Spurs.
Williamson had been sidelined since preseason due to a knee injury but dazzled in his debut, scoring 17 straight points at one point and hitting all four of his three-point attempts.
But how did other NBA greats fare in their first games?
Bill Russell - 6 points, 16 rebounds, one assist (December 22, 1956)
Prior to Russell's NBA debut, the Boston Globe had asked whether it was possible to "be too good to be overrated". No pressure, kid.
Russell did not make any of his four free throws and went 3-of-11 shooting in 16 minutes. However, a man who would go on to be an 11-time NBA champion shone in other facets, grabbing 16 boards and blocking three straight Bob Pettit shots.
Wilt Chamberlain - 43 points, 28 rebounds, one assist (October 24, 1959)
A star at high school and college, the 7ft 1in center's bow for the Philadelphia Warriors was eagerly anticipated and he did not disappoint, racking up the points and rebounds.
It was a sign of things to come and Chamberlain won both the Rookie of the Year and MVP awards in his first season.
Kareem Abdul-Jabbar - 29 points, 12 rebounds, six assists (October 18, 1969)
The broadcast of this debut included the line "the whole country has waited for it", a reflection of the attention the 7ft 1in Milwaukee Bucks center commanded at the time.
Abdul-Jabbar, then known as Lew Alcindor, scored 29 of his NBA record 38,387 points that night and he went on to be named to 19 All-Star Games.
Magic Johnson - 26 points, eight rebounds, four assists (October 12, 1979)
The first overall pick in the 1979 NBA Draft came to a Lakers team that featured Abdul-Jabbar, and it was the veteran's buzzer-beater that delivered the win against the San Diego Clippers.
A pumped-up Johnson certainly impressed, though, and his zeal for the game was evident when he jumped on Abdul-Jabbar amid wild celebrations at the end.
Larry Bird - 14 points, 10 rebounds, five assists (October 12, 1979)
Johnson was not the only future Hall of Famer debuting on that night in October 1979 as Celtics great Bird was also making his first appearance.
The Lakers man might have had more points, but Bird had the double-double and he, not Johnson, would go on to be named Rookie of the Year. Both men won three MVPs and were named to 12 All-Star Games.
Michael Jordan - 16 points, six rebounds, seven assists (October 26, 1984)
There was little indication of what was to come when Jordan put up solid but not spectacular numbers against the Washington Bullets.
He would soon find his groove, though, averaging 28.2 points in a campaign that ended with the Rookie of the Year award. Five MVPs and six championships would follow for perhaps the greatest of them all.
LeBron James - 25 points, six rebounds, nine assists (October 29, 2003)
A man well-versed in dealing with insane hype, James' NBA debut for his hometown Cleveland Cavaliers was delayed because another game went into overtime and ESPN did not want TV audiences to miss a second of the 18-year-old's bow.
Cleveland lost but 'The Chosen One' delivered exactly what the television executives were looking for, a steal and a dunk providing the first of many highlight-reel plays the four-time MVP would produce.