Harden and Westbrook like to control the ball but D'Antoni is confident the latter will fit into Houston's line-up without any drastic changes to accommodate the All-Stars.
"We're not changing much," D'Antoni said on the The Woj Pod while discussing the addition of Westbrook. "We'll tweak it, but to say you've gotta change and you can't win that way, that's B.S."
Some critics believe the Rockets do not spread the ball around enough and play too much isolation.
Now, some are questioning whether it will be even more challenging to play that type of offense with both Harden and Westbrook, who are two ball-dominant players, on the court.
D'Antoni, however, does not think it will be a problem because the two want to play together, and they previously teamed up in Oklahoma City.
"They’ll make it work," D'Antoni said. "Do we sometimes go too much one-on-one? Yeah. Do we sometimes iso or not move enough? Yeah, we do sometimes. But I can also make the argument that sometimes teams over-pass. You try to find the balance of what is best for your players."
D'Antoni explained the Rockets will find what works best for both players to maximise their talents.
"I will start looking now at tape and trying to figure out the dynamics between the two and how they played in Oklahoma City and how it's changed since then, in the Olympics," D'Antoni said.
"But it's exciting. Whenever you have great talent, it's exciting because it gives you a chance to win, and that's what we all want to do. But it'll be my job to maximise their talents and what they do best, and it should be really good.
"I saw it in USA Basketball. You put [the stars] all together and they want to make it work, it doesn't matter. The more talent you have, the better it is. And I think right now with this duo and other people, it'll work. Now, to what degree, we'll see."