Davis suffered a sprained thumb midway through the first quarter, joining the Nets' Kyrie Irving on the sidelines after he aggravated a facial injury in the sides' previous meeting on Thursday.
Star Lakers signing Davis tweaked his thumb while going up to block a shot at the rim, staying in the game for a short period before heading to the locker room for further evaluation.
He came back to the sidelines with an ice pack taped to his right hand and was ruled out for the rest of the game.
Davis served as the starting center, finishing the game with six points while shooting 2-of-7 from the field - both buckets coming off assists from LeBron James.
Anthony Davis will get his sprained right thumb tested tomorrow upon the team’s return to L.A.— Mike Trudell (@LakersReporter) October 12, 2019
The former New Orleans Pelicans superstar added three rebounds and two blocks in 12 minutes before leaving due to the injury.
Los Angeles were able to keep it close through the first half but saw the Nets pull clear in the third quarter as Caris LeVert shone in Irving's absence.
LeVert left the previous clash early with a knock, but he scored 22 points on 8-of-11 shooting and grabbed four rebounds. Taurean Prince also played a big role off the bench with 14 points.
The game brought to an end a trip to China that has been clouded in controversy stemming from a since-deleted tweet by Daryl Morey earlier this week, with the Houston Rockets GM supporting anti-government protesters in Hong Kong.
The two scheduled fixtures went ahead but all media availability was cancelled, overshadowing what had been expected to be a celebration of the NBA in one of its key international markets.
As the teams return to the United States, the Lakers' next preseason game is set for Monday against the Golden State Warriors at Staples Center.
The Nets host the Toronto Raptors next on Friday at Barclays Center.