Beaubier, who raced at Donington Park in his season of 125cc Grand Prix racing, will join Brit Alex Lowes on the British-based factory Yamaha team.
"I feel really fortunate that the Pata Yamaha Official WorldSBK Team is giving me this opportunity to be a part of the team for the weekend while Sylvain is healing up,” Beaubier said in a team release. “I'm also thankful that Yamaha U.S. is allowing me to do this in the middle of our season. It will be a tough weekend with lots of learning, but I'm going to do my best and have fun."
The race will be the start of a three-race stint for Beaubier as he travels to England for the Donington round, May 27-29, then heads to Road America for the Honda Superbike Showdown of Wisconsin, June 3-5, before concluding the three straight weekends with the Honda Showdown of Alabama at Barber Motorsports Park, June 10-12.
Lowes, meanwhile, will be racing after undergoing surgery on Wednesday to plate his broken left clavicle, the result of a race-two crash in Malaysia on Sunday.