Herrera, who joined PSG in July after his contract at Manchester United expired, played in last week's 2-1 victory over Rennes in the Trophee des Champions as he rounded off a busy pre-season with his new club.
But PSG confirmed Spanish midfielder Herrera, 29, injured his left calf in training on Wednesday and will face three to four weeks on the sidelines.
📍@AnderHerrera injured his left calf this morning at the end of training.— Paris Saint-Germain (@PSG_English) August 7, 2019
He will resume training with the group in three to four weeks depending on the evolution of his injury.
PSG head coach Thomas Tuchel has the likes of €18million signing Pablo Sarabia available in midfield, as well as the likes of Marco Verratti, Idrissa Gueye and Julian Draxler, but the loss of Herrera just four days before PSG's clash with Nimes is nevertheless a significant blow.
Herrera made 22 Premier League appearances for United in 2018-19 but his opportunities were restricted by hamstring and ankle injuries throughout the campaign.