Diego Simeone and Antoine Griezmann are among five new positive cases of coronavirus at Atletico Madrid.
Midfielders Koke and Hector Herrera and Portugal star Joao Felix also returned positive results in the club's latest round of testing.
The Spanish champions said all five are asymptomatic and isolating at home.
COVID-19 infections have been recorded at several LaLiga clubs in recent days, with Barcelona having had 10 positive tests this week alone.
On Wednesday, Real Madrid confirmed Thibaut Courtois, Eduardo Camavinga, Federico Valverde and Vinicius Junior had all tested positive for the virus, while Sevilla recorded five positives during the short mid-season break in Spain.
Valencia face Espanyol on Friday before most sides return to action on Sunday, with Atletico taking on high-flying neighbors Rayo Vallecano at the Wanda Metropolitano.