As a precautionary measure, the Uruguayan midfielder has been removed from Real Madrid's matchday squad and is currently self-isolating.
Injuries and positive COVID-19 tests have forced Zinedine Zidane into including five Real Madrid Castilla players for Sunday's trip to the Coliseum Alfonso Perez.
Meanwhile, Ferland Mendy is also out after sustaining a calf injury.
Getafe vs. Real Madrid - Sunday @ 3pm ET / Noon PT on beIN SPORTS
"Real Madrid C. F informs that our player Fede Valverde has been in isolation since yesterday, Saturday 17 April, after being in direct contact with a person who has tested positive for Covid-19, although the player has tested negative in all the tests that he has undergone.
"Fede Valverde will not be available for the match against Getafe C. F. today."