Gerard Pique said it was hard to see Real Madrid dropping points between now and the end of the season after Barcelona handed Zinedine Zidane's team a huge title boost.
Pique could not inspire Barcelona to find a breakthrough at the Ramon Sanchez Pizjuan stadium, leaving the race for glory wide open again.
He said afterwards: "It's going to be difficult to win this league. We're going to do everything we can but very few points will be lost.
"From what I've seen in recent weeks, it's going to be very difficult for Real Madrid to lose points."
Lionel Messi went close with a first-half free-kick and provided a familiar spark at times, but Barcelona faded after a bright opening 30 minutes.
Pique felt he and his team-mates missed an opportunity to take another three points, but he might later reflect on how it might have been worse.
Sevilla defender Sergio Reguilon, on loan from Real Madrid, had a glorious last-gasp chance but made a hash of a close-range shot and Marc-Andre ter Stegen made a comfortable save.
After this weekend, both frontrunners will have eight games left to play in the league.
Asked if it felt as though two points had got away in Seville, Pique said: "Yes, because we were in control and had more chances. They looked a bit tired. I think we were good with the ball but there was little space. We couldn't get the goal."