The composition of the Round of 16 is dominated by teams from Argentina and Brazil, with each country represented by six teams, while two Paraguayan, one Chilean and one Ecuadorian sides make up the remaining four aspirants.
The Round of 16 will start on July 13, while the quarter-final and semi-final fixtures will run between August and September.
The one-off final will be played on November 20, at the Estadio Centenario in Montevideo, Uruguay.
Round of 16 matchups:
A. Defensa y Justicia (ARG) vs Flamengo (BRA)
B. Boca Juniors (ARG) vs Atletico Mineiro (BRA)
C. Universidad Catolica (CHI) vs Palmeiras (BRA)
D. Cerro Porteño (PAR) vs Fluminense (BRA)
E. Velez Sarsfield (ARG) vs Barcelona (ECU)
F. Sao Paulo (BRA) vs Racing (ARG)
G. River Plate (ARG) vs Argentinos Juniors (ARG)
H. Olimpia (PAR) vs Internacional (BRA)