Vinicius Junior earned a recall to the Brazil squad on Friday as head coach Tite explained his intention to rotate his less experienced players.
Bruno Guimaraes made way for Arthur, while Rodrigo Caio held onto his spot in the group and Felipe was dropped for Eder Militao, who only made his first appearance of the season for Madrid last weekend.
Liverpool goalkeeper Alisson and Manchester City striker Gabriel Jesus were included as expected after missing last month's matches through injury, with Santos and Matheus Cunha consequently left out.
"For the young players it's a matter of process, of maturity in their clubs. [Their selection depends on] the best moment, the degree of confidence they have," said Tite.
"For this reason, I'll sometimes use Vinicius, Rodrygo, Bruno Guimaraes...
"[Vinicius] is a player that offers width, goes one on one, has extraordinary physical attributes. Say a normal car has five gears – he has six or seven."
Brazil sit top of the CONMEBOL World Cup qualifying section after wins over Bolivia and Peru in their opening fixtures.
The Selecao are scheduled to entertain Venezuela and travel to Uruguay during the next international break in November.
Alisson (Liverpool), Ederson (Manchester City), Weverton (Palmeiras); Alex Telles (Manchester United), Danilo (Juventus), Eder Militao (Real Madrid), Gabriel Menino (Palmeiras), Marquinhos (Paris Saint-Germain), Renan Lodi (Atletico Madrid), Rodrigo Caio (Flamengo), Thiago Silva (Chelsea); Arthur (Juventus), Casemiro (Real Madrid), Douglas Luiz (Aston Villa), Everton Ribeiro (Flamengo), Fabinho (Liverpool), Philippe Coutinho (Barcelona); Everton (Benfica), Gabriel Jesus (Manchester City), Neymar (Paris Saint-Germain), Richarlison (Everton), Roberto Firmino (Liverpool), Vinicius Junior (Real Madrid).