Marquinhos has warned his Brazil team-mates to be "100 per cent" focused on the threat of Uruguay striker Edinson Cavani in Tuesday's 2022 World Cup qualifying clash.
The Uruguayan left PSG at the end of the 2019-20 campaign as the club's all-time record goalscorer having found the net 200 times.
Indeed, only Lionel Messi (432) and Cristiano Ronaldo (416) have scored more goals in Europe's top five leagues since Cavani (250) debuted for Palermo in 2007.
Brazil have won all three of their qualifiers so far, but Marquinhos says they need to be acutely aware of the danger posed by Cavani – who joined Manchester United on a free transfer in October – in Montevideo if they are to extend their perfect start.
"For me, it was very good to work with Cavani because he is a great attacker," he said. "In confrontations you had to be very careful with him and try to cancel him in the best way.
"I really like to face great attackers, to be able to raise my level and train in the best way. That is what makes you improve and grow every day.
"Cavani is a very decisive player and one who gives a lot to his teams. We know how important he has been for his team. He plays everywhere on the field, attacks and defends.
"We will have to be 100 per cent focused because at the slightest mistake, he can score a goal."
Cavani scored his 51st international goal in Friday's impressive 3-0 qualifying win over Colombia and will likely start up front alongside Luis Suarez against Brazil, the Atletico Madrid striker also scoring in the victory in Barranquilla.
Marquinhos is well aware of the danger posed by the potent pair, but he remains quietly confident Brazil's defense has enough experience to keep them quiet.
"We are always concerned with the great attackers," he added. "They are players that I will have to face individually, but ours is a collective work.
"There are many things we can do to make the game difficult for those players and make it easier for us in defense. Sure, we are concerned, but collectively we will try to limit them."